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Genetics and mechanisms of NT5C2-driven chemotherapy resistance in relapsed ALL
Mutations in the cytosolic 5′ nucleotidase II (NT5C2) gene drive resistance to thiopurine chemotherapy in relapsed acute lymphoblastic leukemia (ALL). Mechanistically, NT5C2 mutant proteins have increased nucleotidase activity as a result of altered activating and autoregulatory switch-off mechanism...
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| Vydáno v: | Blood |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society of Hematology
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6533602/ https://ncbi.nlm.nih.gov/pubmed/30910786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2019-01-852392 |
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