Mutational and functional genetics mapping of chemotherapy resistance mechanisms in relapsed acute lymphoblastic leukemia

Multi-agent combination chemotherapy can be curative in acute lymphoblastic leukemia (ALL). Still, patients with primary refractory disease or with relapsed leukemia have a very poor prognosis. Here we integrate an in-depth dissection of the mutational landscape across diagnostic and relapsed pediat...

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Veröffentlicht in:Nat Cancer
Hauptverfasser: Oshima, Koichi, Zhao, Junfei, Pérez-Durán, Pablo, Brown, Jessie A., Patiño-Galindo, Juan Angel, Chu, Timothy, Quinn, Aidan, Gunning, Thomas, Belver, Laura, Ambesi-Impiombato, Alberto, Tosello, Valeria, Wang, Zhengqiang, Sulis, Maria Luisa, Kato, Motohiro, Koh, Katsuyoshi, Paganin, Maddalena, Basso, Giuseppe, Balbin, Milagros, Nicolas, Concepcion, Gastier-Foster, Julie M., Devidas, Meenakshi, Loh, Mignon L., Paietta, Elisabeth, Tallman, Martin S., Rowe, Jacob M., Litzow, Mark, Minden, Mark D., Meijerink, Jules, Rabadan, Raul, Ferrando, Adolfo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011577/
https://ncbi.nlm.nih.gov/pubmed/33796864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-020-00124-1
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