Curcumin induces apoptosis in JAK2‐mutated cells by the inhibition of JAK2/STAT and mTORC1 pathways

Myeloproliferative neoplasms are chronic myeloid cancers divided in Philadelphia positive and negative. The JAK2 V617F is the most common mutation in Philadelphia negative patients and results in a constitutive activation of the JAK/STAT pathway, conferring a proliferative advantage and apoptosis in...

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Bibliographic Details
Published in:J Cell Mol Med
Main Authors: Petiti, Jessica, Rosso, Valentina, Lo Iacono, Marco, Panuzzo, Cristina, Calabrese, Chiara, Signorino, Elisabetta, Pironi, Lucrezia, Cartellà, Antonio, Bracco, Enrico, Pergolizzi, Barbara, Beltramo, Tiziana, Fava, Carmen, Cilloni, Daniela
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533565/
https://ncbi.nlm.nih.gov/pubmed/31033209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14326
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