HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

Iron and heme play central roles in the production of red blood cells, but the underlying mechanisms remain incompletely understood. Heme-regulated eIF2α kinase (HRI) controls translation by phosphorylating eIF2α. Here, we investigate the global impact of iron, heme, and HRI on protein translation i...

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Udgivet i:eLife
Main Authors: Zhang, Shuping, Macias-Garcia, Alejandra, Ulirsch, Jacob C, Velazquez, Jason, Butty, Vincent L, Levine, Stuart S, Sankaran, Vijay G, Chen, Jane-Jane
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533081/
https://ncbi.nlm.nih.gov/pubmed/31033440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46976
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