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HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis
Iron and heme play central roles in the production of red blood cells, but the underlying mechanisms remain incompletely understood. Heme-regulated eIF2α kinase (HRI) controls translation by phosphorylating eIF2α. Here, we investigate the global impact of iron, heme, and HRI on protein translation i...
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| Yayımlandı: | eLife |
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| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
eLife Sciences Publications, Ltd
2019
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6533081/ https://ncbi.nlm.nih.gov/pubmed/31033440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46976 |
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