HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

Iron and heme play central roles in the production of red blood cells, but the underlying mechanisms remain incompletely understood. Heme-regulated eIF2α kinase (HRI) controls translation by phosphorylating eIF2α. Here, we investigate the global impact of iron, heme, and HRI on protein translation i...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Zhang, Shuping, Macias-Garcia, Alejandra, Ulirsch, Jacob C, Velazquez, Jason, Butty, Vincent L, Levine, Stuart S, Sankaran, Vijay G, Chen, Jane-Jane
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2019
Konular:
Cell Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533081/
https://ncbi.nlm.nih.gov/pubmed/31033440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46976
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