The polyploid state restricts hepatocyte proliferation and liver regeneration

The liver contains a mixture of hepatocytes with diploid or polyploid (tetraploid, octaploid, etc.) nuclear content. Polyploid hepatocytes are commonly found in adult mammals, representing ~90% of the entire hepatic pool in rodents. The cellular and molecular mechanisms that regulate polyploidizatio...

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Vydáno v:Hepatology
Hlavní autoři: Wilkinson, Patrick D., Delgado, Evan R., Alencastro, Frances, Leek, Madeleine P., Roy, Nairita, Weirich, Matthew P., Stahl, Elizabeth C., Otero, P. Anthony, Chen, Maelee I., Brown, Whitney K., Duncan, Andrew W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532408/
https://ncbi.nlm.nih.gov/pubmed/30244478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30286
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