The polyploid state restricts hepatocyte proliferation and liver regeneration

The liver contains a mixture of hepatocytes with diploid or polyploid (tetraploid, octaploid, etc.) nuclear content. Polyploid hepatocytes are commonly found in adult mammals, representing ~90% of the entire hepatic pool in rodents. The cellular and molecular mechanisms that regulate polyploidizatio...

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Publicado en:Hepatology
Autores principales: Wilkinson, Patrick D., Delgado, Evan R., Alencastro, Frances, Leek, Madeleine P., Roy, Nairita, Weirich, Matthew P., Stahl, Elizabeth C., Otero, P. Anthony, Chen, Maelee I., Brown, Whitney K., Duncan, Andrew W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532408/
https://ncbi.nlm.nih.gov/pubmed/30244478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30286
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