Polyploid Hepatocytes Facilitate Adaptation and Regeneration to Chronic Liver Injury

The liver contains diploid and polyploid hepatocytes (tetraploid, octaploid, etc.), with polyploids comprising ≥90% of the hepatocyte population in adult mice. Polyploid hepatocytes form multipolar spindles in mitosis, which lead to chromosome gains/losses and random aneuploidy. The effect of aneupl...

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Udgivet i:Am J Pathol
Main Authors: Wilkinson, Patrick D., Alencastro, Frances, Delgado, Evan R., Leek, Madeleine P., Weirich, Matthew P., Otero, P. Anthony, Roy, Nairita, Brown, Whitney K., Oertel, Michael, Duncan, Andrew W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547059/
https://ncbi.nlm.nih.gov/pubmed/30928253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2019.02.008
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