The polyploid state restricts hepatocyte proliferation and liver regeneration

The liver contains a mixture of hepatocytes with diploid or polyploid (tetraploid, octaploid, etc.) nuclear content. Polyploid hepatocytes are commonly found in adult mammals, representing ~90% of the entire hepatic pool in rodents. The cellular and molecular mechanisms that regulate polyploidizatio...

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Bibliografische gegevens
Gepubliceerd in:Hepatology
Hoofdauteurs: Wilkinson, Patrick D., Delgado, Evan R., Alencastro, Frances, Leek, Madeleine P., Roy, Nairita, Weirich, Matthew P., Stahl, Elizabeth C., Otero, P. Anthony, Chen, Maelee I., Brown, Whitney K., Duncan, Andrew W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532408/
https://ncbi.nlm.nih.gov/pubmed/30244478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30286
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