Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains

The cytoplasmic accumulation of the nuclear TAR DNA-binding protein 43 (TDP-43) is a pathologic hallmark in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and other neurological disorders. However, most transgenic TDP-43 rodent models show predominant nuclear distribution of TDP-4...

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Dades bibliogràfiques
Publicat a:Acta Neuropathol
Autors principals: Yin, Peng, Guo, Xiangyu, Yang, Weili, Yan, Sen, Yang, Su, Zhao, Ting, Sun, Qiang, Liu, Yunbo, Li, Shihua, Li, Xiao-Jiang
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2019
Matèries:
Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6531422/
https://ncbi.nlm.nih.gov/pubmed/30810811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-01979-0
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