Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain

BACKGROUND: TAR DNA-binding protein 43 (TDP-43) is a nuclear protein, but it is redistributed in the neuronal cytoplasm in both amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Because small transgenic animal models often lack cytoplasmic TDP-43, how the cytoplasmic...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Wang, Guohao, Yang, Huaqiang, Yan, Sen, Wang, Chuan-En, Liu, Xudong, Zhao, Bentian, Ouyang, Zhen, Yin, Peng, Liu, Zhaoming, Zhao, Yu, Liu, Tao, Fan, Nana, Guo, Lin, Li, Shihua, Li, Xiao-Jiang, Lai, Liangxue
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557629/
https://ncbi.nlm.nih.gov/pubmed/26334913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0036-5
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