Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents

There is a paramount need for expanding the drug armamentarium to counter the growing problem of drug-resistant tuberculosis. Salicyl-AMS, an inhibitor of salicylic acid adenylation enzymes, is a first-in-class antibacterial lead compound for the development of tuberculosis drugs targeting the biosy...

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Udgivet i:Biochemistry
Main Authors: Bythrow, Glennon V., Mohandas, Poornima, Guney, Tezcan, Standke, Lisa C., Germain, Gabrielle A., Lu, Xuequan, Ji, Cheng, Levendosky, Keith, Chavadi, Sivagami Sundaram, Tan, Derek S., Quadri, Luis E. N.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6530907/
https://ncbi.nlm.nih.gov/pubmed/30582694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01153
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