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Design, synthesis, and biological evaluation of α-hydroxyacyl-AMS inhibitors of amino acid adenylation enzymes

Biosynthesis of bacterial natural-product virulence factors is emerging as a promising antibiotic target. Many such natural products are produced by nonribosomal peptide synthetases (NRPS) from amino acid precursors. To develop selective inhibitors of these pathways, we have previously described ami...

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Dades bibliogràfiques
Publicat a:Bioorg Med Chem Lett
Autors principals: Davis, Tony D., Mohandas, Poornima, Chiriac, Maria I., Bythrow, Glennon V., Quadri, Luis E. N., Tan, Derek S.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079767/
https://ncbi.nlm.nih.gov/pubmed/27692545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.09.027
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