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Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors
Adenylate-forming enzymes are a mechanistic superfamily that are involved in diverse biochemical pathways. They catalyze ATP-dependent activation of carboxylic acid substrates as reactive acyl adenylate (acyl-AMP) intermediates and subsequent coupling to various nucleophiles to generate ester, thioe...
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| Publicado no: | J Antibiot (Tokyo) |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6594144/ https://ncbi.nlm.nih.gov/pubmed/30982830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41429-019-0171-2 |
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