(CTG)n repeat-mediated dysregulation of MBNL1 and MBNL2 expression during myogenesis in DM1 occurs already at the myoblast stage

Myotonic dystrophy type 1 (DM1) is a severe neuromuscular disorder caused by the expression of trinucleotide repeat-containing DMPK transcripts. Abnormally expanded (CUG)n repeats in these transcripts form hairpin-like structures that cause the RNA to accumulate in the cell nucleus by sequestering i...

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Vydáno v:PLoS One
Hlavní autoři: André, Laurène M., van Cruchten, Remco T. P., Willemse, Marieke, Wansink, Derick G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6530876/
https://ncbi.nlm.nih.gov/pubmed/31116797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217317
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