Molecular mechanisms of IL‐18BP regulation in DLD‐1 cells: pivotal direct action of the STAT1/GAS axis on the promoter level

Interleukin (IL)‐18, formerly known as interferon (IFN)‐γ‐inducing factor, is a crucial mediator of host defence and inflammation. Control of IL‐18 bioactivity by its endogenous antagonist IL‐18 binding protein (IL‐18BP) is a major objective of immunoregulation. IL‐18BP is strongly up‐regulated by I...

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Bibliographische Detailangaben
Veröffentlicht in:J Cell Mol Med
Hauptverfasser: Bachmann, Malte, Paulukat, Jens, Pfeilschifter, Josef, Mühl, Heiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2008
Schlagworte:
Molecular Medicine
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529978/
https://ncbi.nlm.nih.gov/pubmed/19046253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2008.00604.x
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