A Prominent Role of Interleukin-18 in Acetaminophen-Induced Liver Injury Advocates Its Blockage for Therapy of Hepatic Necroinflammation

Acetaminophen [paracetamol, N-acetyl-p-aminophenol (APAP)]-induced acute liver injury (ALI) not only remains a persistent clinical challenge but likewise stands out as well-characterized paradigmatic model of drug-induced liver damage. APAP intoxication associates with robust hepatic necroinflammati...

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Pubblicato in:Front Immunol
Autori principali: Bachmann, Malte, Pfeilschifter, Josef, Mühl, Heiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809456/
https://ncbi.nlm.nih.gov/pubmed/29472923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00161
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