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GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor
The mammalian target of rapamycin complex 1 (mTORC1) regulates cell growth, metabolism, and autophagy. Extensive research has focused on pathways that activate mTORC1 like growth factors and amino acids; however, much less is known about signaling cues that directly inhibit mTORC1 activity. Here, we...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6529218/ https://ncbi.nlm.nih.gov/pubmed/31112131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43038 |
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