GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

The mammalian target of rapamycin complex 1 (mTORC1) regulates cell growth, metabolism, and autophagy. Extensive research has focused on pathways that activate mTORC1 like growth factors and amino acids; however, much less is known about signaling cues that directly inhibit mTORC1 activity. Here, we...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Jewell, Jenna L, Fu, Vivian, Hong, Audrey W, Yu, Fa-Xing, Meng, Delong, Melick, Chase H, Wang, Huanyu, Lam, Wai-Ling Macrina, Yuan, Hai-Xin, Taylor, Susan S, Guan, Kun-Liang
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2019
Matèries:
Cancer Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529218/
https://ncbi.nlm.nih.gov/pubmed/31112131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43038
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