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Catalytic, Enantioselective Synthesis of Cyclic Carbamates from Dialkyl Amines by CO(2)-Capture: Discovery, Development, and Mechanism

Cyclic carbamates are a common feature of small molecule therapeutics, offering a constrained hydrogen bond acceptor that is both polar and sterically small. Methods for their preparation most often focus first on aminoalcohol synthesis and then reaction with phosgene or its equivalent. This report...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Am Chem Soc
Main Authors: Yousefi, Roozbeh, Struble, Thomas J., Payne, Jenna L., Vishe, Mahesh, Schley, Nathan D., Johnston, Jeffrey N.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2018
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528176/
https://ncbi.nlm.nih.gov/pubmed/30582326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b11793
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