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Gold(I)-Catalyzed Enantioselective Intramolecular Dehydrative Amination of Allylic Alcohols with Carbamates

A 1:2 mixture of [(S)-2](AuCl)(2) [(S)-2 = (S)-DTBM-MeOBIPHEP] and AgClO(4) catalyzes the intramolecular enantioselective dehydrative amination of allylic alcohols with carbamates to form five- and six-membered aliphatic nitrogen heterocycles in high yield with up to 95% ee.

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Detalhes bibliográficos
Main Authors: Mukherjee, Paramita, Widenhoefer, Ross A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429348/
https://ncbi.nlm.nih.gov/pubmed/22294357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201107877
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