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Local membrane charge regulates β(2) adrenergic receptor coupling to G(i3)
The β(2) adrenergic receptor (β(2)AR) signals through both G(s) and G(i) in cardiac myocytes, and the G(i) pathway counteracts the G(s) pathway. However, G(i) coupling is much less efficient than G(s) coupling in most cell-based and biochemical assays, making it difficult to study β(2)AR−G(i) intera...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6527575/ https://ncbi.nlm.nih.gov/pubmed/31110175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10108-0 |
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