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Viewing rare conformations of the β(2) adrenergic receptor with pressure-resolved DEER spectroscopy
The β(2) adrenergic receptor (β(2)AR) is an archetypal G protein coupled receptor (GPCR). One structural signature of GPCR activation is a large-scale movement (ca. 6 to 14 Å) of transmembrane helix 6 (TM6) to a conformation which binds and activates a cognate G protein. The β(2)AR exhibits a low le...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7749303/ https://ncbi.nlm.nih.gov/pubmed/33257561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2013904117 |
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