Viewing rare conformations of the β(2) adrenergic receptor with pressure-resolved DEER spectroscopy

The β(2) adrenergic receptor (β(2)AR) is an archetypal G protein coupled receptor (GPCR). One structural signature of GPCR activation is a large-scale movement (ca. 6 to 14 Å) of transmembrane helix 6 (TM6) to a conformation which binds and activates a cognate G protein. The β(2)AR exhibits a low le...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Lerch, Michael T., Matt, Rachel A., Masureel, Matthieu, Elgeti, Matthias, Kumar, Kaavya Krishna, Hilger, Daniel, Foys, Bryon, Kobilka, Brian K., Hubbell, Wayne L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2020
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749303/
https://ncbi.nlm.nih.gov/pubmed/33257561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2013904117
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