DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions

HIV-1 Envelope (Env) mediates viral-host membrane fusion after binding host-receptor CD4 and coreceptor. Soluble envelopes (SOSIPs), designed to mimic prefusion conformational states of virion-bound envelopes, are proposed immunogens for eliciting neutralizing antibodies, yet only static structures...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Stadtmueller, Beth M., Bridges, Michael D., Dam, Kim-Marie, Lerch, Michael T., Huey-Tubman, Kathryn E., Hubbell, Wayne L., Bjorkman, Pamela J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104740/
https://ncbi.nlm.nih.gov/pubmed/30076100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.06.017
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