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Substrate specificity of the pyrophosphohydrolase LpxH determines the asymmetry of Bordetella pertussis lipid A

Lipopolysaccharides are anchored to the outer membrane of Gram-negative bacteria by a hydrophobic moiety known as lipid A, which potently activates the host innate immune response. Lipid A of Bordetella pertussis, the causative agent of whooping cough, displays unusual structural asymmetry with resp...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Arenas, Jesús, Pupo, Elder, de Jonge, Eline, Pérez-Ortega, Jesús, Schaarschmidt, Joerg, van der Ley, Peter, Tommassen, Jan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527161/
https://ncbi.nlm.nih.gov/pubmed/30926608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004680
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