Novel MASP-2 inhibitors developed via directed evolution of human TFPI1 are potent lectin pathway inhibitors

Lignende værker

• Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2
  af: Héja, Dávid, et al.
  Udgivet: (2012)
• MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked
  af: Dobó, József, et al.
  Udgivet: (2016)
• Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2
  af: Héja, Dávid, et al.
  Udgivet: (2012)
• Quantitative Characterization of the Activation Steps of Mannan-binding Lectin (MBL)-associated Serine Proteases (MASPs) Points to the Central Role of MASP-1 in the Initiation of the Complement Lectin Pathway
  af: Megyeri, Márton, et al.
  Udgivet: (2013)
• MASP-1 Increases Endothelial Permeability
  af: Debreczeni, Márta L., et al.
  Udgivet: (2019)