Identification and quantification of defective virus genomes in high throughput sequencing data using DVG-profiler, a novel post-sequence alignment processing algorithm

Most viruses are known to spontaneously generate defective viral genomes (DVG) due to errors during replication. These DVGs are subgenomic and contain deletions that render them unable to complete a full replication cycle in the absence of a co-infecting, non-defective helper virus. DVGs, especially...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Bosma, Trent J., Karagiannis, Konstantinos, Santana-Quintero, Luis, Ilyushina, Natalia, Zagorodnyaya, Tatiana, Petrovskaya, Svetlana, Laassri, Majid, Donnelly, Raymond P., Rubin, Steven, Simonyan, Vahan, Sauder, Christian J.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524942/
https://ncbi.nlm.nih.gov/pubmed/31100083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216944
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