Identification and quantification of defective virus genomes in high throughput sequencing data using DVG-profiler, a novel post-sequence alignment processing algorithm

Most viruses are known to spontaneously generate defective viral genomes (DVG) due to errors during replication. These DVGs are subgenomic and contain deletions that render them unable to complete a full replication cycle in the absence of a co-infecting, non-defective helper virus. DVGs, especially...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Bosma, Trent J., Karagiannis, Konstantinos, Santana-Quintero, Luis, Ilyushina, Natalia, Zagorodnyaya, Tatiana, Petrovskaya, Svetlana, Laassri, Majid, Donnelly, Raymond P., Rubin, Steven, Simonyan, Vahan, Sauder, Christian J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524942/
https://ncbi.nlm.nih.gov/pubmed/31100083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216944
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