Dexibuprofen amide derivatives as potential anticancer agents: synthesis, in silico docking, bioevaluation, and molecular dynamic simulation

BACKGROUND: The amide derivatives of nonsteroidal anti-inflammatory drugs have been reported to possess antitumor activity. The present work describes the synthesis of dexibuprofen amide analogues (4a–j) as potential anticancer agents. METHODS: The title amides (4a–j) were obtained by simple nucleop...

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Publicado en:Drug Des Devel Ther
Autores principales: Ashraf, Zaman, Mahmood, Tariq, Hassan, Mubashir, Afzal, Samina, Rafique, Hummera, Afzal, Khurram, Latip, Jalifah
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove Medical Press 2019
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524612/
https://ncbi.nlm.nih.gov/pubmed/31190743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S178595
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