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Synthesis, Bioevaluation and Molecular Dynamic Simulation Studies of Dexibuprofen–Antioxidant Mutual Prodrugs

Dexibuprofen–antioxidant conjugates were synthesized with the aim to reduce its gastrointestinal effects. The esters analogs of dexibuprofen 5a–c were obtained by reacting its –COOH group with chloroacetyl derivatives 3a–c. The in vitro hydrolysis data confirmed that synthesized prodrugs 5a–c were s...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Ashraf, Zaman, Alamgeer, Rasool, Raqiqatur, Hassan, Mubashir, Ahsan, Haseeb, Afzal, Samina, Afzal, Khurram, Cho, Hongsik, Kim, Song Ja
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187951/
https://ncbi.nlm.nih.gov/pubmed/28009827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17122151
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