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Flurbiprofen–antioxidant mutual prodrugs as safer nonsteroidal anti-inflammatory drugs: synthesis, pharmacological investigation, and computational molecular modeling

Flurbiprofen–antioxidant mutual prodrugs were synthesized to reduce the gastrointestinal (GI) effects associated with flurbiprofen. For reducing the GI toxicity, the free carboxylic group (–COOH) was temporarily masked by esterification with phenolic –OH of natural antioxidants vanillin, thymol, umb...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Ashraf, Zaman, Alamgeer, Kanwal, Munazza, Hassan, Mubashir, Abdullah, Sahar, Waheed, Mamuna, Ahsan, Haseeb, Kim, Song Ja
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968865/
https://ncbi.nlm.nih.gov/pubmed/27555750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S109318
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