Synthesis and Biological Evaluation of RGD–Cryptophycin Conjugates for Targeted Drug Delivery

Cryptophycins are potent tubulin polymerization inhibitors with picomolar antiproliferative potency in vitro and activity against multidrug-resistant (MDR) cancer cells. Because of neurotoxic side effects and limited efficacy in vivo, cryptophycin-52 failed as a clinical candidate in cancer treatmen...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Pharmaceutics
Huvudupphovsmän: Borbély, Adina, Figueras, Eduard, Martins, Ana, Esposito, Simone, Auciello, Giulio, Monteagudo, Edith, Di Marco, Annalise, Summa, Vincenzo, Cordella, Paola, Perego, Raffaella, Kemker, Isabell, Frese, Marcel, Gallinari, Paola, Steinkühler, Christian, Sewald, Norbert
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2019
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6523311/
https://ncbi.nlm.nih.gov/pubmed/30939768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11040151
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk