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Altered expression of insulin-degrading enzyme and regulator of calcineurin in the rat intracerebral streptozotocin model and human apolipoprotein E-ε4–associated Alzheimer's disease
INTRODUCTION: This study assesses insulin-degrading enzyme (IDE) and regulator of calcineurin 1 (RCAN1) as potential mediators of brain insulin deficiency and neurodegeneration in experimental and human Alzheimer's disease (AD). METHODS: Temporal lobes from Long Evans rats treated with intracer...
Gespeichert in:
| Veröffentlicht in: | Alzheimers Dement (Amst) |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6522644/ https://ncbi.nlm.nih.gov/pubmed/31193223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dadm.2019.03.004 |
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