Altered expression of insulin-degrading enzyme and regulator of calcineurin in the rat intracerebral streptozotocin model and human apolipoprotein E-ε4–associated Alzheimer's disease

INTRODUCTION: This study assesses insulin-degrading enzyme (IDE) and regulator of calcineurin 1 (RCAN1) as potential mediators of brain insulin deficiency and neurodegeneration in experimental and human Alzheimer's disease (AD). METHODS: Temporal lobes from Long Evans rats treated with intracer...

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Detalhes bibliográficos
Publicado no:Alzheimers Dement (Amst)
Main Authors: Delikkaya, Büşra, Moriel, Natalia, Tong, Ming, Gallucci, Gina, de la Monte, Suzanne M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522644/
https://ncbi.nlm.nih.gov/pubmed/31193223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dadm.2019.03.004
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