Combination of 5-fluorouracil and thymoquinone targets stem cell gene signature in colorectal cancer cells

Cancer stem cells (CSCs) residing in colorectal cancer tissues have tumorigenic capacity and contribute to chemotherapeutic resistance and disease relapse. It is well known that the survival of colorectal CSCs after 5-fluorouracil (5-FU)-based therapy leads to cancer recurrence. Thus CSCs represent...

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Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Ndreshkjana, Benardina, Çapci, Aysun, Klein, Volker, Chanvorachote, Pithi, Muenzner, Julienne K., Huebner, Kerstin, Steinmann, Sara, Erlenbach-Wuensch, Katharina, Geppert, Carol I., Agaimy, Abbas, Ballout, Farah, El-Baba, Chirine, Gali-Muhtasib, Hala, Roehe, Adriana Vial, Hartmann, Arndt, Tsogoeva, Svetlana B., Schneider-Stock, Regine
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522523/
https://ncbi.nlm.nih.gov/pubmed/31097715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1611-4
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