Cytoplasmic p21 Mediates 5-Fluorouracil Resistance by Inhibiting Pro-Apoptotic Chk2

The oncogenic cytoplasmic p21 contributes to cancer aggressiveness and chemotherapeutic failure. However, the molecular mechanisms remain obscure. Here, we show for the first time that cytoplasmic p21 mediates 5-Fluorouracil (5FU) resistance by shuttling p-Chk2 out of the nucleus to protect the tumo...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Maiuthed, Arnatchai, Ninsontia, Chuanpit, Erlenbach-Wuensch, Katharina, Ndreshkjana, Benardina, Muenzner, Julienne K., Caliskan, Aylin, Husayn, Ahmed P., Chaotham, Chatchai, Hartmann, Arndt, Vial Roehe, Adriana, Mahadevan, Vijayalakshmi, Chanvorachote, Pithi, Schneider-Stock, Regine
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6210175/
https://ncbi.nlm.nih.gov/pubmed/30304835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers10100373
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