Identification of genetic variants associated with tacrolimus metabolism in kidney transplant recipients by extreme phenotype sampling and next generation sequencing

An extreme phenotype sampling (EPS) model with targeted next-generation sequencing (NGS) identified genetic variants associated with tacrolimus (Tac) metabolism in subjects from the Deterioration of Kidney Allograft Function (DeKAF) Genomics cohort which included 1,442 European Americans (EA) and 34...

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Udgivet i:Pharmacogenomics J
Main Authors: Dorr, Casey R., Wu, Baolin, Remmel, Rory P., Muthusamy, Amutha, Schladt, David P., Abrahante, Juan E., Guan, Weihua, Mannon, Roslyn B., Matas, Arthur J., Oetting, William S., Jacobson, Pamala A., Israni, Ajay K.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522337/
https://ncbi.nlm.nih.gov/pubmed/30442921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41397-018-0063-z
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