Tacrolimus Trough and Dose Intra-Patient Variability and CYP3A5 Genotype: Effects on Acute Rejection and Graft Failure in European American and African American Kidney Transplant Recipients

BACKGROUND: Suboptimal immunosuppression after kidney transplantation contributes to toxicity and loss of efficacy. Little is known regarding the impact of intra-patient variability of tacrolimus (TAC) doses and troughs in the early post-transplant period or the influence of genetic variants on vari...

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Vydáno v:Clin Transplant
Hlavní autoři: Seibert, Stephan R, Schladt, David P, Wu, Baolin, Guan, Weihua, Dorr, Casey, Remmel, Rory P, Matas, Arthur J, Mannon, Roslyn B, Israni, Ajay K, Oetting, William S, Jacobson, Pamala A
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317347/
https://ncbi.nlm.nih.gov/pubmed/30318646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ctr.13424
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