Tacrolimus Elimination in Four Patients With a CYP3A5*3/*3 CYP3A4*22/*22 Genotype Combination

Cytochrome P450 3A5 (CYP3A5) and cytochrome P450 3A4 (CYP3A4) are the predominate enzymes responsible for tacrolimus metabolism. The presence of CYP3A4 and CYP3A5 genetic variants significantly affects tacrolimus clearance and dose requirements. CYP3A5*3 is a loss-of-function variant resulting in no...

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Detalhes bibliográficos
Publicado no:Pharmacotherapy
Main Authors: Scheibner, Aileen, Remmel, Rory, Schladt, David, Oetting, William S., Guan, Weihua, Wu, Baolin, Dorr, Casey, Israni, Ajay, Jacobson, Pamala A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6265082/
https://ncbi.nlm.nih.gov/pubmed/29804290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/phar.2131
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