CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism

Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 engineering of the CYP3A5 *3 locus (rs776746) in human liver cell line HuH-7 (CYP3A5 *3/*3) has led to three CYP3A5 *1 cell lines by deletion of the exon 3B splice junction or point mutation. Cell lines CYP3A5 *1/*3 sd (single d...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Drug Metab Dispos
Hoofdauteurs: Dorr, Casey R., Remmel, Rory P., Muthusamy, Amutha, Fisher, James, Moriarity, Branden S., Yasuda, Kazuto, Wu, Baolin, Guan, Weihua, Schuetz, Erin G., Oetting, William S., Jacobson, Pamala A., Israni, Ajay K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Pharmacology and Experimental Therapeutics 2017
Onderwerpen:
Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518718/
https://ncbi.nlm.nih.gov/pubmed/28533324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.117.076307
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items