Organ-Specific Expression of IL-1 Receptor Results in Severe Liver Injury in Type I Interferon Receptor Deficient Mice

Upon treatment with polyinosinic:polycytidylic acid [poly(I:C)], an artificial double-stranded RNA, type I interferon receptor-deficient (IFNAR(−/−)) mice develop severe liver injury seen by enhanced alanine aminotransferase (ALT) activity in the serum that is not observed in their wildtype (WT) cou...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Anzaghe, Martina, Resch, Theresa, Schaser, Elea, Kronhart, Stefanie, Diez, Clara, Niles, Marc A., Korotkova, Eugenia, Schülke, Stefan, Wolfheimer, Sonja, Kreuz, Dorothea, Wingerter, Marion, Bartolomé Rodríguez, María Matilde, Waibler, Zoe
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6521796/
https://ncbi.nlm.nih.gov/pubmed/31143178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01009
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