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TGN1412 Induces Lymphopenia and Human Cytokine Release in a Humanized Mouse Model
Therapeutic monoclonal antibodies (mAbs) such as the superagonistic, CD28-specific antibody TGN1412, or OKT3, an anti-CD3 mAb, can cause severe adverse events including cytokine release syndrome. A predictive model for mAb-mediated adverse effects, for which no previous knowledge on severe adverse e...
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| Publicado no: | PLoS One |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4784892/ https://ncbi.nlm.nih.gov/pubmed/26959227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149093 |
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