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The calm after the cytokine storm: lessons from the TGN1412 trial
In March 2006, a phase I study of the superagonistic anti-CD28 antibody TGN1412 caused a massive cytokine storm and multiorgan failure in six healthy human volunteers. Such a profound impact on the immune system was not predicted by preclinical animal studies. In a study from this issue of the JCI,...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2269728/ https://ncbi.nlm.nih.gov/pubmed/18357347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35382 |
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