Were monocytes responsible for initiating the cytokine storm in the TGN1412 clinical trial tragedy?

The precise biological mechanisms that caused the TGN1412 clinical trial tragedy (also known as ‘The Elephant Man Clinical Trial’) in March 2006 remain a mystery to this day. It is assumed widely that the drug used in this trial (TGN1412) bound to CD28 on T lymphocytes and following activation of th...

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Bibliografiske detaljer
Main Authors: Sandilands, G P, Wilson, M, Huser, C, Jolly, L, Sands, W A, McSharry, C
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2010
Fag:
Translational Studies
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026555/
https://ncbi.nlm.nih.gov/pubmed/20964641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2010.04264.x
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