In vitro and in vivo Metabolism of a Potent Inhibitor of Soluble Epoxide Hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea

1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (TPPU) is a potent soluble epoxide hydrolase (sEH) inhibitor that is used extensively in research for modulating inflammation and protecting against hypertension, neuropathic pain, and neurodegeneration. Despite its wide use in various...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Front Pharmacol
Päätekijät: Wan, Debin, Yang, Jun, McReynolds, Cindy B., Barnych, Bogdan, Wagner, Karen M., Morisseau, Christophe, Hwang, Sung Hee, Sun, Jia, Blöcher, René, Hammock, Bruce D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2019
Aiheet:
Pharmacology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520522/
https://ncbi.nlm.nih.gov/pubmed/31143115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00464
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