Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU): resulting drug levels and modulation of oxylipin pattern

Epoxides from polyunsaturated fatty acids (PUFAs) are potent lipid mediators. In vivo stabilization of these epoxides by blockade of the soluble epoxide hydrolase (sEH) leads to anti-inflammatory, analgesic and normotensive effects. Therefore, sEH inhibitors (sEHi) are a promising new class of drugs...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Prostaglandins Other Lipid Mediat
Autori principali: Ostermann, Annika I., Herbers, Jan, Willenberg, Ina, Chen, Rongjun, Hwang, Sung Hee, Greite, Robert, Morisseau, Christophe, Gueler, Faikah, Hammock, Bruce D., Schebb, Nils Helge
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688279/
https://ncbi.nlm.nih.gov/pubmed/26117215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.prostaglandins.2015.06.005
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi