Soluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3- (1-propionylpiperidin-4-yl) urea attenuates bleomycin-induced pulmonary fibrosis in mice

Epoxyeicosatrienoic acids (EETs), the metabolites of arachidonic acid derived from the cytochrome P450 (CYP450) epoxygenases, are mainly metabolized by soluble epoxide hydrolase (sEH) to their corresponding diols. EETs, but not their diols, have anti-inflammatory properties, and inhibition of sEH mi...

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Vydáno v:Cell Tissue Res
Hlavní autoři: Zhou, Yong, Sun, Guo-Ying, Liu, Tian, Duan, Jia-Xi, Zhou, Hui-Fang, Lee, Kin Sing, Hammock, Bruce D., Fang, Xiang, Guan, Cha-Xiang, Jiang, Jian-Xin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738109/
https://ncbi.nlm.nih.gov/pubmed/26310139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00441-015-2262-0
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