Soluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3- (1-propionylpiperidin-4-yl) urea attenuates bleomycin-induced pulmonary fibrosis in mice

Epoxyeicosatrienoic acids (EETs), the metabolites of arachidonic acid derived from the cytochrome P450 (CYP450) epoxygenases, are mainly metabolized by soluble epoxide hydrolase (sEH) to their corresponding diols. EETs, but not their diols, have anti-inflammatory properties, and inhibition of sEH mi...

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Veröffentlicht in:Cell Tissue Res
Hauptverfasser: Zhou, Yong, Sun, Guo-Ying, Liu, Tian, Duan, Jia-Xi, Zhou, Hui-Fang, Lee, Kin Sing, Hammock, Bruce D., Fang, Xiang, Guan, Cha-Xiang, Jiang, Jian-Xin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738109/
https://ncbi.nlm.nih.gov/pubmed/26310139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00441-015-2262-0
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