In vitro and in vivo Metabolism of a Potent Inhibitor of Soluble Epoxide Hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea

1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (TPPU) is a potent soluble epoxide hydrolase (sEH) inhibitor that is used extensively in research for modulating inflammation and protecting against hypertension, neuropathic pain, and neurodegeneration. Despite its wide use in various...

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Publicat a:Front Pharmacol
Autors principals: Wan, Debin, Yang, Jun, McReynolds, Cindy B., Barnych, Bogdan, Wagner, Karen M., Morisseau, Christophe, Hwang, Sung Hee, Sun, Jia, Blöcher, René, Hammock, Bruce D.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520522/
https://ncbi.nlm.nih.gov/pubmed/31143115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00464
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