Loss of BRUCE reduces cellular energy level and induces autophagy by driving activation of the AMPK-ULK1 autophagic initiating axis

Autophagy is an intracellular catabolic system. It delivers cellular components to lysosomes for degradation and supplies nutrients that promote cell survival under stress conditions. Although much is known regarding starvation-induced autophagy, the regulation of autophagy by cellular energy level...

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Veröffentlicht in:PLoS One
Hauptverfasser: Che, Lixiao, Yang, Xingyuan, Ge, Chunmin, El-Amouri, Salim S., Wang, Qi-En, Pan, Dao, Herzog, Thomas J., Du, Chunying
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519829/
https://ncbi.nlm.nih.gov/pubmed/31091257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216553
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