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AMPK-dependent phosphorylation of ULK1 induces autophagy
AMP-activated protein kinase (AMPK) is a highly conserved cellular energy sensor that plays a central role in metabolic homeostasis. A recent study in Science (Egan et al., 2011) identifies ULK1 as a substrate for AMPK phosphorylation, a modification required for selective autophagy of mitochondria...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3056410/ https://ncbi.nlm.nih.gov/pubmed/21284977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.01.009 |
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